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Local genomicsfor macOS.

With Genome, you can analyse sequencing data, investigate variants and document results. Right on your Mac.

Download GenomeExplore features
Genome 2.1.1 availablemacOS 14 or later · Apple siliconProcessed locally · No telemetry

GenomeYour data. Your Mac.

Genome: workflow selection with the details of the chosen workflow
Choose a workflow. Check its inputs. Follow the analysis.
  1. FASTQCheck raw reads
  2. BAM / CRAMAligned to a reference
  3. AnalysesHLA · KIR · PGx · mtDNA
  4. PDF reportSources and limits

From sequence data to a report.

From FASTQ, BAM or CRAM to a PDF: check data quality, investigate variants, and keep sources and technical limits visible.

Explore all analyses →

  • Prepare your data

    Start with paired FASTQ files or an existing BAM/CRAM. Genome checks inputs and data quality before analysis.

  • Investigate a question

    Look up an rsID, examine a gene or run specialised HLA, KIR, pharmacogenetic and mitochondrial analyses. Keep coverage and quality in view.

  • Document your results

    Bring completed analyses together in a PDF, with sources, quality information and technical limits.

A closer look

One rsID. Straight to your BAM.

Search a .bam file directly by rs number. Genome presents the genotype alongside read coverage and quality, without first exporting a genotype file.

Your BAM and reads stay on your Mac. Only an optional rsID lookup may send the requested identifier to NCBI.

Read the BAM search guide
Genome rsID searchSchematic
Enter rs followed by digits. This sketch does not look up or analyse the identifier.
  1. Enter an rsIDThe identifier stays the starting point.
  2. Resolve the referenceGenome can request the rsID mapping from NCBI.
  3. Search local readsGenome examines the selected BAM or CRAM on your Mac.
  4. Review evidenceCoverage and quality remain visible with the result.

The sketch highlights the workflow only. No BAM data or search result is shown.

Explore Genome analyses

Install with one command

Genome is downloaded, verified and installed in your Applications folder.

curl -q --proto '=https' --proto-redir '=https' --tlsv1.2 -fsSL https://pjlabs.dev/install/genome.sh | sh
  • Reads the release manifest
  • Verifies the SHA-256 checksum
  • Installs to Applications

Also from PJ Labs

Look up. Try out. Read on.

Genome App-Icon

Genome for macOS

Explore Genome in detail.

Explore the features, check file formats and follow the guide to your first analysis.

Download Genome

Vellum · macOS

Your voice. Your Mac.

Free German dictation directly into your text field. Local speech recognition, optional correction and a history you control. Offline after the model download.

Discover Vellum and download ↗